Viagra professional: Top five myths about this popular drug

How Sildenafil Compares To Other ED Drugs Sildenafil, sold under the trade names Viagra and Revatio, is a drug used primarily for the treatment of erectile dysfunction. It is the prototypical phosphodiesterase type V inhibitor, which has been of a significant help in saving the sex-life  of many that have suffered erectile dysfunction. Pharmacokinetics of Sildenafil Pharmacokinetics refers to what the body does to a drug. Sildenafil is administered both orally and parenterally as an intravenous bolus. It has a bioavailability of about 40%, and its plasma protein binding is about 96%. Its onset of action is within 20 to 30 minutes, and its pharmacological effects last for about 2 hours. It is metabolized by the the liver microsomal enzyme system majorly CYP3A4, and to some extent CYP2C9. Its metabolite N-desmethylsildenafil has an approximate potency of 50% for PDE5 receptors (phosphodiesterase type 5 receptors). The elimination half life for sildenafil is about 3 to 4 hours, and it is excreted largely in feces and a small portion is excreted in urine. The oral dosage form is sildenafil tablets available as viagra or revatio (both having different indicatons), whereas the intravenous formulation is a sildenafil salt, sildenafil citrate.  I am a young Continue Reading